The Need for a Reliable Score to Guide ED Management

  • Thiruganasambandamoorthy V, et al. ED management of syncope: need for standardization and improved risk stratification. Intern Emerg Med. 2015;10:619-627. pdf

  • Baugh CW, Sun BC. Variation in diagnostic testing for older patients with syncope in the ED. Am J Emerg Med. 2019;37:810-816. pdf

Recent Reviews of Available ED Syncope Risk-stratifying Tools

  • Sweanor RA, et al. Multivariable risk scores for predicting short term outcomes for ED patients with unexplained syncope: a systematic review. Acad Emerg Med. 2021;28(5):502-510. pdf

  • Tannenbaum L, et al. Can I send this syncope patient home from the ED? J Emerg Med. 2021;61(6):801-809. pdf

Original Derivation and Validation Studies of the Canadian Syncope Risk Score

  • Thiruganasambandamoorthy V, et al. Development of the Canadian Syncope Risk Score to predict serious adverse events after ED assessment of syncope. CMAJ. 2016;188:E289-e298. pdf

  • Thiruganasambandamoorthy V, et al. Multicenter ED validation of the Canadian Syncope Risk Score. JAMA Intern Med. 2020;180:737-744. pdf

  • Thiruganasambandamoorthy V, et al. Personalised risk prediction following ED assessment for syncope. Emerg Med J. 2021 Nov 5 [Online ahead of print]. pdf

Validation Outside Canada

  • Solbiati M, et al. Multicentre external validation of the Canadian Syncope Risk Score to predict adverse events and comparison with clinical judgement. Emerg Med J. 2021;38(9):701-706. pdf

This small Italian study has several fatal flaws that prevent it from being a true test of the Canadian score. For more on this see Thiruganasambandamoorthy V. Response to Solbiati. Emerg Med J. 2022 March 9. Online ahead of print. pdf

  • Zimmermann T, et al; BASEL IX Investigators. International validation of the Canadian Syncope Risk Score: A cohort study. Ann Intern Med. 2022 Apr 26. Online ahead of print. pdf

Can Machine Learning Algorithms Improve the Canadian Score?

  • Grant L, et al. Machine learning versus traditional methods for the development of risk stratification scores: a case study using original Canadian Syncope Risk Score data. Intern Emerg Med. 2021 Nov 3. Online ahead of print. pdf